Is it difficult to get a credit card with wells fargo with a credit score of 720?

Assuming your debt to income looks good and you have a job, then no it shouldn't be a problem.

Although, Wells Fargo is known to be a bad credit lender. As such, their rates and fees will be much higher.

Try your credit union. They will treat you much better.

Credit score is only one of the criteria. You must show an ability to repay. Job history and income are reviewed.